Assay Detail
Binding
CHEMBL3579895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by LC/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.67 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412099 | — | — | 1 | 8.22 |
| CHEMBL483894 | — | — | 1 | 8.15 |
| CHEMBL180650 | — | — | 1 | 7.64 |
| CHEMBL1076694 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412099 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL483894 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL180650 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1076694 | — | IC50 | = | 216.0 | nM | 6.67 |