Assay Detail
Binding
CHEMBL3579956
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental HexA using pNPGlcNAc substrate
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Beta-N-acetyl-D-hexosaminidase-A/B (CHEMBL3038485) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.57 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577321 | — | — | 1 | 4.82 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.77 |
| CHEMBL3577317 | — | — | 1 | 4.75 |
| CHEMBL281412 | — | — | 1 | 4.75 |
| CHEMBL22148 | — | — | 1 | 4.50 |
| CHEMBL3577322 | — | — | 1 | 4.47 |
| CHEMBL21778 | — | — | 1 | 4.40 |
| CHEMBL3577323 | — | — | 1 | 4.37 |
| CHEMBL3577324 | — | — | 1 | 4.33 |
| CHEMBL3577319 | — | — | 1 | - |
| CHEMBL3577320 | — | — | 1 | - |
| CHEMBL3577318 | — | — | 1 | - |
| CHEMBL21357 | — | — | 1 | - |
| CHEMBL3577316 | — | — | 1 | - |
| CHEMBL3577315 | — | — | 1 | - |
| CHEMBL3577314 | — | — | 1 | - |
| CHEMBL3577313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577321 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3577317 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL281412 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL22148 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3577322 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL21778 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3577323 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3577324 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL3577319 | — | IC50 | > | 1400000.0 | nM | - |
| CHEMBL3577320 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL3577318 | — | IC50 | > | 410000.0 | nM | - |
| CHEMBL21357 | — | IC50 | > | 560000.0 | nM | - |
| CHEMBL3577316 | — | IC50 | > | 940000.0 | nM | - |
| CHEMBL3577315 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL3577314 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL3577313 | — | IC50 | > | 2100000.0 | nM | - |