Assay Detail
Binding
CHEMBL3580143
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Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.98 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577442 | — | — | 1 | 9.00 |
| CHEMBL175436 | ANABAENOPEPTIN F | — | 1 | 8.82 |
| CHEMBL368684 | ANABAENOPEPTIN B | — | 1 | 8.82 |
| CHEMBL3577334 | — | — | 1 | 8.72 |
| CHEMBL3577425 | — | — | 1 | 8.52 |
| CHEMBL3577435 | — | — | 1 | 8.40 |
| CHEMBL3577440 | — | — | 1 | 8.40 |
| CHEMBL3577439 | — | — | 1 | 8.40 |
| CHEMBL3577433 | — | — | 1 | 8.15 |
| CHEMBL3577434 | — | — | 1 | 8.05 |
| CHEMBL3577432 | — | — | 1 | 7.82 |
| CHEMBL3577426 | — | — | 1 | 7.82 |
| CHEMBL3577436 | — | — | 1 | 7.75 |
| CHEMBL3577336 | — | — | 1 | 7.72 |
| CHEMBL3577335 | — | — | 1 | 7.51 |
| CHEMBL3577438 | — | — | 1 | 7.42 |
| CHEMBL3577424 | — | — | 1 | 7.41 |
| CHEMBL3577427 | — | — | 1 | 7.24 |
| CHEMBL3577441 | — | — | 1 | 7.00 |
| CHEMBL3577437 | — | — | 1 | 6.96 |
| CHEMBL3577423 | — | — | 1 | 6.96 |
| CHEMBL3577337 | — | — | 1 | 6.92 |
| CHEMBL3577325 | — | — | 1 | 6.89 |
| CHEMBL3577330 | — | — | 1 | 6.77 |
| CHEMBL3577329 | — | — | 1 | 6.72 |
| CHEMBL3577443 | — | — | 1 | 6.60 |
| CHEMBL3577326 | — | — | 1 | 6.41 |
| CHEMBL446236 | OSCILLAMIDE Y | — | 1 | 6.40 |
| CHEMBL3577428 | — | — | 1 | 6.34 |
| CHEMBL3577445 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577442 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL175436 | ANABAENOPEPTIN F | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL368684 | ANABAENOPEPTIN B | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3577334 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3577425 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3577435 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3577440 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3577439 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3577433 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3577434 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3577432 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3577426 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3577436 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3577336 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3577335 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3577438 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3577424 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3577427 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3577441 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3577437 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3577423 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3577337 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3577325 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3577330 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3577329 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3577443 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3577326 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL446236 | OSCILLAMIDE Y | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3577428 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3577445 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3577327 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3577444 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3577328 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3577338 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3577429 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3577422 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3577333 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3577332 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3577430 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3577431 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3577446 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL3577331 | — | IC50 | = | 59000.0 | nM | 4.23 |