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Assay Detail

CHEMBL3580214

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition after 20 to 70 hrs by Real-time RTCA iCELLgence system
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.
Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M.
J Med Chem (2015) 58 : 4590 -4609
PubMed 25923950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.26 5.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3578214 1 5.43
CHEMBL3578215 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3578214 IC50 = 3700.0 nM 5.43
CHEMBL3578215 IC50 = 8300.0 nM 5.08