Assay Detail
Binding
CHEMBL3580244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli recombinant KPC-2 assessed as substrate nitrocefin degradation preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.78 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | 7.16 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 5.80 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3317857 | VABORBACTAM | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL404 | TAZOBACTAM | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL777 | CLAVULANIC ACID | Ki | = | 41200.0 | nM | 4.38 |