Assay Detail
Functional
CHEMBL3580300
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Antiviral activity against Influenza B virus B/Malaysia/2506/04 assessed as reduction in plaque formation after 48 hrs by plaque reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.67 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577823 | — | — | 1 | 4.96 |
| CHEMBL3577821 | — | — | 1 | 4.77 |
| CHEMBL3577802 | — | — | 1 | 4.50 |
| CHEMBL3577817 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577823 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3577821 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3577802 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3577817 | — | EC50 | = | 36000.0 | nM | 4.44 |