Assay Detail
Binding
CHEMBL3580368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli recombinant P99 assessed as substrate nitrocefin degradation preincubated for 10 mins followed by substrate addition measured every 10 secs for 10 mins by spectrophotometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.62 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | 7.28 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 5.96 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3317857 | VABORBACTAM | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL404 | TAZOBACTAM | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL777 | CLAVULANIC ACID | Ki | = | 1106000.0 | nM | - |