Assay Detail
Functional
CHEMBL3582780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as cell viability after 5 days by CellTiter-Glo assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.38 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581682 | — | — | 1 | 8.70 |
| CHEMBL3581681 | — | — | 1 | 8.70 |
| CHEMBL3581693 | BRILANESTRANT | 2.0 | 1 | 8.70 |
| CHEMBL3581692 | — | — | 1 | 8.40 |
| CHEMBL3581688 | — | — | 1 | 8.40 |
| CHEMBL3581680 | — | — | 1 | 8.40 |
| CHEMBL195515 | — | — | 1 | 8.30 |
| CHEMBL3581691 | — | — | 1 | 8.30 |
| CHEMBL3581641 | — | — | 1 | 8.22 |
| CHEMBL3581638 | — | — | 1 | 8.05 |
| CHEMBL3581683 | — | — | 1 | 7.92 |
| CHEMBL3581685 | — | — | 1 | 7.92 |
| CHEMBL3581645 | — | — | 1 | 7.92 |
| CHEMBL3581644 | — | — | 1 | 7.85 |
| CHEMBL3581684 | — | — | 1 | 7.82 |
| CHEMBL3581678 | — | — | 1 | 7.80 |
| CHEMBL3580674 | — | — | 1 | 7.68 |
| CHEMBL3581690 | — | — | 1 | 7.60 |
| CHEMBL3581646 | — | — | 1 | 7.51 |
| CHEMBL3581643 | — | — | 1 | 7.44 |
| CHEMBL3581687 | — | — | 1 | 7.33 |
| CHEMBL3581640 | — | — | 1 | 7.28 |
| CHEMBL3581637 | — | — | 1 | 7.25 |
| CHEMBL3581689 | — | — | 1 | 7.16 |
| CHEMBL3581686 | — | — | 1 | 7.00 |
| CHEMBL3581679 | — | — | 1 | 6.82 |
| CHEMBL3581636 | — | — | 1 | 6.80 |
| CHEMBL3581677 | — | — | 1 | 6.70 |
| CHEMBL3581675 | — | — | 1 | 6.68 |
| CHEMBL226267 | ARZOXIFENE | 3.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581682 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3581693 | BRILANESTRANT | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3581681 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3581692 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3581688 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3581680 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL195515 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3581691 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3581641 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3581638 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3581685 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3581645 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3581683 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3581644 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3581684 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3581678 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3580674 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3581690 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3581646 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3581643 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3581687 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3581640 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3581637 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3581689 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3581686 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3581679 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3581636 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3581677 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3581675 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL226267 | ARZOXIFENE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL44426 | PIPENDOXIFENE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3581642 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL33899 | — | IC50 | = | 985.0 | nM | 6.01 |
| CHEMBL3581639 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL3581635 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL3581676 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3581634 | — | IC50 | - | — | - |