Assay Detail
Binding
CHEMBL3582891
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Inhibition of recombinant human placental AdoHcy hydrolase expressed in Escherichia coli BL21 using AdoHcy as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by DTNB coupled assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.18 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64718 | FLUORO-NEPLANOCIN A | — | 1 | 6.62 |
| CHEMBL154745 | — | — | 1 | 6.36 |
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 6.33 |
| CHEMBL310547 | — | — | 1 | 6.32 |
| CHEMBL3580900 | — | — | 1 | 6.04 |
| CHEMBL80375 | — | — | 1 | 5.42 |
| CHEMBL200935 | DEAZANEPLANOCIN A | — | 1 | - |
| CHEMBL3580894 | — | — | 1 | - |
| CHEMBL3580895 | — | — | 1 | - |
| CHEMBL3580896 | — | — | 1 | - |
| CHEMBL3580897 | — | — | 1 | - |
| CHEMBL3580898 | — | — | 1 | - |
| CHEMBL3580899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64718 | FLUORO-NEPLANOCIN A | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL154745 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL310547 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3580900 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL80375 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL200935 | DEAZANEPLANOCIN A | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580894 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580896 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580898 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3580899 | — | IC50 | > | 100000.0 | nM | - |