Assay Detail
Binding
CHEMBL3583384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by Patchexpress patch clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.99 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2204935 | — | — | 1 | 5.47 |
| CHEMBL3582317 | — | — | 1 | 4.92 |
| CHEMBL3582336 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2204935 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3582317 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3582336 | — | IC50 | = | 27000.0 | nM | 4.57 |