Assay Detail
Binding
CHEMBL3583448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Nav1.7 (unknown origin) by electrophysiological assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 9 subunit alpha (CHEMBL4296) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.83 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581056 | — | — | 1 | 6.36 |
| CHEMBL3581058 | — | — | 1 | 6.25 |
| CHEMBL3581050 | — | — | 1 | 6.19 |
| CHEMBL3581059 | — | — | 1 | 6.04 |
| CHEMBL3581054 | — | — | 1 | 5.99 |
| CHEMBL3581053 | — | — | 1 | 5.52 |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581056 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3581058 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3581050 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL3581059 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL3581054 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL3581053 | — | Ki | = | 3030.0 | nM | 5.52 |
| CHEMBL108 | CARBAMAZEPINE | Ki | = | 32700.0 | nM | 4.49 |