Assay Detail
Functional
CHEMBL3583526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MV4-11 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.38 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581661 | — | — | 1 | 7.70 |
| CHEMBL3581660 | — | — | 1 | 7.64 |
| CHEMBL1957266 | — | — | 1 | 7.62 |
| CHEMBL3581662 | — | — | 1 | 7.47 |
| CHEMBL1232461 | MOLIBRESIB | 2.0 | 1 | 7.03 |
| CHEMBL2017291 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581661 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3581660 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1957266 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3581662 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1232461 | MOLIBRESIB | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2017291 | — | IC50 | = | 162.0 | nM | 6.79 |