Assay Detail
Binding
CHEMBL3583803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (CHEMBL2321630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.75 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581716 | — | — | 1 | 9.00 |
| CHEMBL3581717 | — | — | 1 | 8.92 |
| CHEMBL3581718 | — | — | 1 | 8.68 |
| CHEMBL3581715 | — | — | 1 | 8.66 |
| CHEMBL3581732 | — | — | 1 | 8.66 |
| CHEMBL3581736 | — | — | 1 | 8.60 |
| CHEMBL3581734 | — | — | 1 | 8.51 |
| CHEMBL3581730 | — | — | 1 | 8.47 |
| CHEMBL3581735 | — | — | 1 | 8.44 |
| CHEMBL3581724 | — | — | 1 | 8.43 |
| CHEMBL3581727 | — | — | 1 | 8.17 |
| CHEMBL3581728 | — | — | 1 | 8.14 |
| CHEMBL3581731 | — | — | 1 | 8.00 |
| CHEMBL3581729 | — | — | 1 | 7.85 |
| CHEMBL3581723 | — | — | 1 | 7.64 |
| CHEMBL3581733 | — | — | 1 | 7.55 |
| CHEMBL3581719 | — | — | 1 | 7.39 |
| CHEMBL3581739 | — | — | 1 | 7.37 |
| CHEMBL3581726 | — | — | 1 | 6.89 |
| CHEMBL3581737 | — | — | 1 | 6.89 |
| CHEMBL3581738 | — | — | 1 | 6.89 |
| CHEMBL3581720 | — | — | 1 | 6.77 |
| CHEMBL3581725 | — | — | 1 | 6.57 |
| CHEMBL3581722 | — | — | 1 | 5.68 |
| CHEMBL3581721 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581716 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3581717 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3581718 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3581715 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3581732 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3581736 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3581734 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3581730 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3581735 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3581724 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3581727 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3581728 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3581731 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3581729 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3581723 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3581733 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3581719 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3581739 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3581726 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3581737 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3581738 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3581720 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3581725 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3581722 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3581721 | — | IC50 | = | 3300.0 | nM | 5.48 |