Assay Detail
Functional
CHEMBL3583822
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Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.06 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.40 |
| CHEMBL264190 | — | — | 1 | 7.42 |
| CHEMBL3582446 | — | — | 1 | 6.38 |
| CHEMBL3582445 | — | — | 1 | 6.07 |
| CHEMBL50056 | — | — | 1 | 6.02 |
| CHEMBL441988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL264190 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3582446 | — | EC50 | = | 415.0 | nM | 6.38 |
| CHEMBL3582445 | — | EC50 | = | 854.0 | nM | 6.07 |
| CHEMBL50056 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL441988 | — | EC50 | > | 100000.0 | nM | - |