Assay Detail
Binding
CHEMBL3583831
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Inhibition of human CYP11B2 expressed in V79 cells incubated for 1 hr before 11-deoxycorticosterone substrate addition by HTRF-based assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.07 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582482 | — | — | 1 | 9.70 |
| CHEMBL3582477 | — | — | 1 | 9.52 |
| CHEMBL3582474 | — | — | 1 | 9.40 |
| CHEMBL3582470 | — | — | 1 | 9.40 |
| CHEMBL3582481 | — | — | 1 | 9.30 |
| CHEMBL3582483 | — | — | 1 | 9.22 |
| CHEMBL3582471 | — | — | 1 | 9.22 |
| CHEMBL3582475 | — | — | 1 | 9.10 |
| CHEMBL3582476 | — | — | 1 | 9.00 |
| CHEMBL3582467 | — | — | 1 | 8.92 |
| CHEMBL3582469 | — | — | 1 | 8.68 |
| CHEMBL3582465 | — | — | 1 | 8.66 |
| CHEMBL3582478 | MSD-CYP11B2 | — | 1 | 8.64 |
| CHEMBL3582451 | — | — | 1 | 8.40 |
| CHEMBL3582472 | — | — | 1 | 8.33 |
| CHEMBL3582480 | — | — | 1 | 8.09 |
| CHEMBL3582479 | — | — | 1 | 7.99 |
| CHEMBL3582447 | — | — | 1 | 7.92 |
| CHEMBL3582452 | — | — | 1 | 7.80 |
| CHEMBL3582473 | — | — | 1 | 7.65 |
| CHEMBL3582468 | — | — | 1 | 7.62 |
| CHEMBL3582459 | — | — | 1 | 7.55 |
| CHEMBL3582449 | — | — | 1 | 7.46 |
| CHEMBL3582457 | — | — | 1 | 7.31 |
| CHEMBL3582460 | — | — | 1 | 6.97 |
| CHEMBL3582450 | — | — | 1 | 6.86 |
| CHEMBL3582458 | — | — | 1 | 6.66 |
| CHEMBL3582466 | — | — | 1 | 6.59 |
| CHEMBL3582455 | — | — | 1 | 6.25 |
| CHEMBL3582456 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582482 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3582477 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3582470 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3582474 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3582481 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3582483 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3582471 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3582475 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3582476 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3582467 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3582469 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3582465 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3582478 | MSD-CYP11B2 | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3582451 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3582472 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3582480 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3582479 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL3582447 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3582452 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3582473 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL3582468 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3582459 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3582449 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3582457 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3582460 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3582450 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL3582458 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3582466 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL3582455 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL3582456 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL3582463 | — | IC50 | = | 1768.0 | nM | 5.75 |
| CHEMBL3582454 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3582453 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3582464 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3582461 | MSD-CYP11B2-Negative-control | IC50 | > | 10000.0 | nM | - |
| CHEMBL3582448 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3582462 | — | IC50 | > | 1000.0 | nM | - |