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Assay Detail

CHEMBL3583864

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Binding
Inhibition of human LDH-A by biochemical assay
ChEMBL ↗
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

L-lactate dehydrogenase A chain (CHEMBL4835) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Labadie S, Dragovich PS, Chen J, Fauber BP, Boggs J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Ho Q, Lai KW, Ma S, Malek S, Peterson D, Purkey HE, Robarge K, Salphati L, Sideris S, Ultsch M, VanderPorten E, Wei B, Xu Q, Yen I, Yue Q, Zhang H, Zhang X, Zhou A.
Bioorg Med Chem Lett (2014) 25 : 75 -82
PubMed 25466195 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 6.79 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3581197 — — 1 8.22
CHEMBL3581201 — — 1 7.82
CHEMBL3581200 — — 1 7.60
CHEMBL3581204 — — 1 7.52
CHEMBL3581205 — — 1 7.52
CHEMBL3581199 — — 1 7.52
CHEMBL3581203 — — 1 7.46
CHEMBL3581194 — — 1 7.40
CHEMBL3581179 — — 1 7.22
CHEMBL3581182 — — 1 7.22
CHEMBL3581184 — — 1 7.07
CHEMBL3581198 — — 1 7.05
CHEMBL3581180 — — 1 7.05
CHEMBL3581177 — — 1 7.00
CHEMBL3581181 — — 1 7.00
CHEMBL3581183 — — 1 6.97
CHEMBL3581186 — — 1 6.92
CHEMBL3581196 — — 1 6.92
CHEMBL3581195 — — 1 6.89
CHEMBL3581178 — — 1 6.77
CHEMBL3581189 — — 1 6.77
CHEMBL3581175 — — 1 6.64
CHEMBL3581173 — — 1 6.62
CHEMBL3581193 — — 1 6.52
CHEMBL3581187 — — 1 6.43
CHEMBL3581176 — — 1 6.43
CHEMBL3581202 — — 1 6.34
CHEMBL3581188 — — 1 6.19
CHEMBL3318469 — — 1 6.06
CHEMBL3581185 — — 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3581197 — IC50 = 6.0 nM 8.22
CHEMBL3581201 — IC50 = 15.0 nM 7.82
CHEMBL3581200 — IC50 = 25.0 nM 7.60
CHEMBL3581204 — IC50 = 30.0 nM 7.52
CHEMBL3581205 — IC50 = 30.0 nM 7.52
CHEMBL3581199 — IC50 = 30.0 nM 7.52
CHEMBL3581203 — IC50 = 35.0 nM 7.46
CHEMBL3581194 — IC50 = 40.0 nM 7.40
CHEMBL3581179 — IC50 = 60.0 nM 7.22
CHEMBL3581182 — IC50 = 60.0 nM 7.22
CHEMBL3581184 — IC50 = 85.0 nM 7.07
CHEMBL3581198 — IC50 = 90.0 nM 7.05
CHEMBL3581180 — IC50 = 90.0 nM 7.05
CHEMBL3581177 — IC50 = 100.0 nM 7.00
CHEMBL3581181 — IC50 = 100.0 nM 7.00
CHEMBL3581183 — IC50 = 108.0 nM 6.97
CHEMBL3581196 — IC50 = 120.0 nM 6.92
CHEMBL3581186 — IC50 = 120.0 nM 6.92
CHEMBL3581195 — IC50 = 130.0 nM 6.89
CHEMBL3581178 — IC50 = 170.0 nM 6.77
CHEMBL3581189 — IC50 = 170.0 nM 6.77
CHEMBL3581175 — IC50 = 230.0 nM 6.64
CHEMBL3581173 — IC50 = 240.0 nM 6.62
CHEMBL3581193 — IC50 = 300.0 nM 6.52
CHEMBL3581176 — IC50 = 370.0 nM 6.43
CHEMBL3581187 — IC50 = 370.0 nM 6.43
CHEMBL3581202 — IC50 = 460.0 nM 6.34
CHEMBL3581188 — IC50 = 640.0 nM 6.19
CHEMBL3318469 — IC50 = 870.0 nM 6.06
CHEMBL3581185 — IC50 = 1100.0 nM 5.96
CHEMBL3581191 — IC50 = 1800.0 nM 5.75
CHEMBL3581174 — IC50 = 2600.0 nM 5.58
CHEMBL3581190 — IC50 = 3500.0 nM 5.46
CHEMBL3581192 — IC50 = 10000.0 nM 5.00