Assay Detail
Binding
CHEMBL3583962
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Inhibition of rhesus monkey CYP11B2 expressed in V79 cells incubated for 1 hr before 11-deoxycorticosterone substrate addition by HTRF-based assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Cell Type | V79 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 1 | 9.52 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582478 | MSD-CYP11B2 | — | 1 | 9.52 |
| CHEMBL3582469 | — | — | 1 | - |
| CHEMBL3582472 | — | — | 1 | - |
| CHEMBL3582477 | — | — | 1 | - |
| CHEMBL3582481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582478 | MSD-CYP11B2 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3582469 | — | Inhibition | - | % | - | |
| CHEMBL3582472 | — | Inhibition | - | % | - | |
| CHEMBL3582477 | — | Inhibition | - | % | - | |
| CHEMBL3582481 | — | Inhibition | - | % | - |