Assay Detail
Binding
CHEMBL3584050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for paclitaxel at 1 uM after 5 days by CellTiter 96 Aqueous assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 7.64 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582168 | — | — | 1 | 8.57 |
| CHEMBL3582155 | — | — | 1 | 8.52 |
| CHEMBL3582156 | — | — | 1 | 8.48 |
| CHEMBL3582149 | — | — | 1 | 8.43 |
| CHEMBL3582170 | — | — | 1 | 8.38 |
| CHEMBL3582167 | — | — | 1 | 8.34 |
| CHEMBL3582154 | — | — | 1 | 8.21 |
| CHEMBL3582169 | — | — | 1 | 8.18 |
| CHEMBL3582153 | — | — | 1 | 8.09 |
| CHEMBL3582148 | — | — | 1 | 8.06 |
| CHEMBL3582180 | — | — | 1 | 8.03 |
| CHEMBL3582166 | — | — | 1 | 7.94 |
| CHEMBL3582165 | — | — | 1 | 7.93 |
| CHEMBL3582162 | — | — | 1 | 7.92 |
| CHEMBL3582139 | — | — | 1 | 7.92 |
| CHEMBL3582159 | — | — | 1 | 7.87 |
| CHEMBL3582158 | — | — | 1 | 7.87 |
| CHEMBL3582182 | — | — | 1 | 7.84 |
| CHEMBL3582143 | — | — | 1 | 7.83 |
| CHEMBL3582157 | — | — | 1 | 7.80 |
| CHEMBL3582179 | — | — | 1 | 7.80 |
| CHEMBL3582152 | — | — | 1 | 7.75 |
| CHEMBL3582164 | — | — | 1 | 7.73 |
| CHEMBL3582151 | — | — | 1 | 7.72 |
| CHEMBL3582137 | — | — | 1 | 7.71 |
| CHEMBL1631996 | — | — | 1 | 7.68 |
| CHEMBL3582147 | — | — | 1 | 7.66 |
| CHEMBL3582146 | — | — | 1 | 7.60 |
| CHEMBL3582178 | — | — | 1 | 7.58 |
| CHEMBL3582183 | — | — | 1 | 7.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582168 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3582155 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3582156 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3582149 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3582170 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3582167 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3582154 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3582169 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3582153 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3582148 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3582180 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL3582166 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL3582165 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL3582139 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3582162 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3582159 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL3582158 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL3582182 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL3582143 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL3582157 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL3582179 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL3582152 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3582164 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL3582151 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3582137 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL1631996 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3582147 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL3582146 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3582178 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL3582183 | — | IC50 | = | 27.8 | nM | 7.56 |
| CHEMBL3582176 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL3582145 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL3582144 | — | IC50 | = | 34.2 | nM | 7.47 |
| CHEMBL3582142 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3582181 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL3582174 | — | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3582150 | — | IC50 | = | 40.1 | nM | 7.40 |
| CHEMBL3582177 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL3582175 | — | IC50 | = | 44.4 | nM | 7.35 |
| CHEMBL3582136 | — | IC50 | = | 45.2 | nM | 7.34 |
| CHEMBL3582173 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL3582163 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3582141 | — | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL3582161 | — | IC50 | = | 67.1 | nM | 7.17 |
| CHEMBL3582140 | — | IC50 | = | 97.1 | nM | 7.01 |
| CHEMBL3582172 | — | IC50 | = | 107.3 | nM | 6.97 |
| CHEMBL3582138 | — | IC50 | = | 112.9 | nM | 6.95 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 124.1 | nM | 6.91 |
| CHEMBL3582160 | — | IC50 | = | 135.9 | nM | 6.87 |