Assay Detail
Binding
CHEMBL3584052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival after 5 days by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.78 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.50 |
| CHEMBL3582149 | — | — | 1 | 6.90 |
| CHEMBL3582168 | — | — | 1 | 6.85 |
| CHEMBL3582148 | — | — | 1 | 6.80 |
| CHEMBL3582155 | — | — | 1 | 6.80 |
| CHEMBL3582167 | — | — | 1 | 6.77 |
| CHEMBL3582156 | — | — | 1 | 6.67 |
| CHEMBL3582170 | — | — | 1 | 6.65 |
| CHEMBL3582169 | — | — | 1 | 6.55 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3582149 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL3582168 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3582148 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL3582155 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL3582167 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL3582156 | — | EC50 | = | 214.0 | nM | 6.67 |
| CHEMBL3582170 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3582169 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 446.0 | nM | 6.35 |