Assay Detail
Functional
CHEMBL3584618
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Cytotoxicity against Wnt-independent human SW480 cells assessed as cell viability after 24 hrs by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.86 | 4.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774404 | — | — | 1 | 4.95 |
| CHEMBL444160 | — | — | 1 | 4.76 |
| CHEMBL3120496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774404 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL444160 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL3120496 | — | IC50 | > | 40000.0 | nM | - |