Assay Detail
Binding
CHEMBL3584688
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Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.49 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581245 | — | — | 1 | 7.82 |
| CHEMBL464099 | — | — | 1 | 7.70 |
| CHEMBL3581254 | — | — | 1 | 7.70 |
| CHEMBL3581252 | — | — | 1 | 7.66 |
| CHEMBL3581255 | — | — | 1 | 7.64 |
| CHEMBL3580670 | — | — | 1 | 7.62 |
| CHEMBL3581250 | — | — | 1 | 7.62 |
| CHEMBL3581248 | — | — | 1 | 7.55 |
| CHEMBL3581249 | — | — | 1 | 7.47 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.43 |
| CHEMBL3581251 | — | — | 1 | 7.42 |
| CHEMBL228082 | GLAUCINE | — | 1 | 7.37 |
| CHEMBL3581253 | — | — | 1 | 7.30 |
| CHEMBL3581247 | — | — | 1 | 7.28 |
| CHEMBL3581256 | — | — | 1 | 7.27 |
| CHEMBL3581246 | — | — | 1 | 7.24 |
| CHEMBL3581244 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581245 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL464099 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3581254 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3581252 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3581255 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3580670 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3581250 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3581248 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3581249 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL42 | CLOZAPINE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3581251 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL228082 | GLAUCINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3581253 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3581247 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL3581256 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL3581246 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3581244 | — | Ki | = | 69.0 | nM | 7.16 |