Assay Detail
Functional
CHEMBL3584880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 cultured in human erythrocytes assessed as inhibition of parasite growth incubated for 48 hrs by YOYO-1 staining based flow cytometry
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.37 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581500 | — | — | 1 | 9.70 |
| CHEMBL3581502 | — | — | 1 | 9.40 |
| CHEMBL3581499 | — | — | 1 | 9.30 |
| CHEMBL3581497 | — | — | 1 | 9.30 |
| CHEMBL3581503 | — | — | 1 | 9.15 |
| CHEMBL3581498 | — | — | 1 | 8.92 |
| CHEMBL3581479 | — | — | 1 | 8.85 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.22 |
| CHEMBL3581504 | — | — | 1 | 8.18 |
| CHEMBL3581501 | — | — | 1 | 7.72 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.68 |
| CHEMBL3581476 | — | — | 1 | 7.64 |
| CHEMBL3581478 | — | — | 1 | 7.09 |
| CHEMBL3581483 | — | — | 1 | 6.96 |
| CHEMBL3581487 | — | — | 1 | 6.92 |
| CHEMBL1761274 | — | — | 1 | 6.92 |
| CHEMBL3581488 | — | — | 1 | 6.82 |
| CHEMBL1761275 | — | — | 1 | 6.82 |
| CHEMBL3581475 | — | — | 1 | 6.77 |
| CHEMBL3581505 | — | — | 1 | 6.72 |
| CHEMBL3581491 | — | — | 1 | 6.72 |
| CHEMBL3581485 | — | — | 1 | 6.68 |
| CHEMBL3581486 | — | — | 1 | 6.62 |
| CHEMBL3581482 | — | — | 1 | 6.36 |
| CHEMBL3581481 | — | — | 1 | 6.33 |
| CHEMBL3581494 | — | — | 1 | 6.10 |
| CHEMBL3581492 | — | — | 1 | 5.75 |
| CHEMBL3581490 | — | — | 1 | 5.18 |
| CHEMBL3581480 | — | — | 1 | 5.03 |
| CHEMBL3581493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581500 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3581502 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3581499 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3581497 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3581503 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3581498 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3581479 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3581504 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3581501 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3581476 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3581478 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3581483 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1761274 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3581487 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1761275 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3581488 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3581475 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3581505 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3581491 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3581485 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3581486 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3581482 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3581481 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3581494 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3581492 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3581490 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL3581480 | — | IC50 | = | 9380.0 | nM | 5.03 |
| CHEMBL3581493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3581484 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3581495 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3581496 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3581489 | — | IC50 | > | 10000.0 | nM | - |