Assay Detail
Binding
CHEMBL3586926
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Inhibition of human collagen prolyl 4-hydroxylase
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.42 | 6.73 |
| IC50 | 1 | 4.89 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332005 | — | — | 1 | 6.73 |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | — | 1 | 6.10 |
| CHEMBL1205641 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332005 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1205641 | — | IC50 | = | 13000.0 | nM | 4.89 |