Assay Detail
Binding
CHEMBL3586964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.55 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | 3.0 | 1 | 9.00 |
| CHEMBL3586473 | — | — | 1 | 8.00 |
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | 7.51 |
| CHEMBL3586468 | — | — | 1 | 7.48 |
| CHEMBL41816 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3586473 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL259084 | MLN-8054 | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3586468 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL41816 | — | IC50 | = | 1700.0 | nM | 5.77 |