Assay Detail
Binding
CHEMBL3586965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.07 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | 3.0 | 1 | 8.15 |
| CHEMBL3586473 | — | — | 1 | 7.75 |
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | 7.47 |
| CHEMBL3586468 | — | — | 1 | 6.77 |
| CHEMBL41816 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3586473 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL259084 | MLN-8054 | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3586468 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL41816 | — | IC50 | = | 6000.0 | nM | 5.22 |