Assay Detail
Binding
CHEMBL3586972
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Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATP
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.84 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | 3.0 | 1 | 9.52 |
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483158 | ALISERTIB | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL259084 | MLN-8054 | Ki | = | 7.0 | nM | 8.15 |