Assay Detail
Binding
CHEMBL3587003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat recombinant nNOS expressed in Escherichia coli by oxyhemoglobin NO assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.19 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586661 | — | — | 1 | 7.77 |
| CHEMBL3586664 | — | — | 1 | 7.62 |
| CHEMBL3586663 | — | — | 1 | 7.47 |
| CHEMBL3586660 | — | — | 1 | 7.46 |
| CHEMBL3586658 | — | — | 1 | 7.21 |
| CHEMBL3586662 | — | — | 1 | 7.17 |
| CHEMBL3586656 | — | — | 1 | 6.89 |
| CHEMBL3586657 | — | — | 1 | 6.72 |
| CHEMBL3586659 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586661 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3586664 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3586663 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3586660 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3586658 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3586662 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL3586656 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3586657 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL3586659 | — | Ki | = | 430.0 | nM | 6.37 |