Assay Detail
Binding
CHEMBL3587046
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Binding affinity to Fe(2) assessed as half maximal concentration required for binding 20 uM Fe(2) in pH 7.0 sodium phosphate buffer
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.41 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586253 | — | — | 1 | 4.58 |
| CHEMBL3586254 | — | — | 1 | 4.57 |
| CHEMBL445558 | — | — | 1 | 4.42 |
| CHEMBL39879 | DIPYRIDYL | — | 1 | 4.37 |
| CHEMBL3586252 | — | — | 1 | 4.11 |
| CHEMBL1577802 | — | — | 1 | - |
| CHEMBL332005 | — | — | 1 | - |
| CHEMBL3586255 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586253 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3586254 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL445558 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL39879 | DIPYRIDYL | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3586252 | — | EC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL1577802 | — | EC50 | - | — | - | |
| CHEMBL332005 | — | EC50 | = | 112000.0 | nM | - |
| CHEMBL3586255 | — | EC50 | - | — | - |