Assay Detail
Functional
CHEMBL3587063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human Jurkat E6-1 cells assessed as reduction in cell proliferation after 48 hrs by WST-1 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat E6.1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.85 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.22 |
| CHEMBL81794 | — | — | 1 | 6.31 |
| CHEMBL3585529 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 6.08 | nM | 8.22 |
| CHEMBL81794 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL3585529 | — | IC50 | = | 965.0 | nM | 6.01 |