Assay Detail
Binding
CHEMBL3587278
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Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of biphenyl-aryl ureas as novel VEGFR-2 inhibitors. Part 4: exploration of diverse hinge-binding fragments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.48 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586072 | — | — | 1 | 9.85 |
| CHEMBL3586071 | — | — | 1 | 9.82 |
| CHEMBL3586057 | — | — | 1 | 9.66 |
| CHEMBL3586049 | — | — | 1 | 9.44 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.32 |
| CHEMBL3586056 | — | — | 1 | 8.66 |
| CHEMBL3586051 | — | — | 1 | 8.34 |
| CHEMBL3586065 | — | — | 1 | 7.88 |
| CHEMBL3586052 | — | — | 1 | 7.20 |
| CHEMBL3586070 | — | — | 1 | 7.00 |
| CHEMBL3586058 | — | — | 1 | 6.14 |
| CHEMBL3586050 | — | — | 1 | - |
| CHEMBL3586053 | — | — | 1 | - |
| CHEMBL3586054 | — | — | 1 | - |
| CHEMBL3586055 | — | — | 1 | - |
| CHEMBL3586059 | — | — | 1 | - |
| CHEMBL3586060 | — | — | 1 | - |
| CHEMBL3586061 | — | — | 1 | - |
| CHEMBL3586063 | — | — | 1 | - |
| CHEMBL3586064 | — | — | 1 | - |
| CHEMBL3586066 | — | — | 1 | - |
| CHEMBL3586062 | — | — | 1 | - |
| CHEMBL3586067 | — | — | 1 | - |
| CHEMBL3586068 | — | — | 1 | - |
| CHEMBL3586075 | — | — | 1 | - |
| CHEMBL3586069 | — | — | 1 | - |
| CHEMBL3586074 | — | — | 1 | - |
| CHEMBL3586073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586072 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3586071 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3586057 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL3586049 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3586056 | — | IC50 | = | 2.19 | nM | 8.66 |
| CHEMBL3586051 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3586065 | — | IC50 | = | 13.26 | nM | 7.88 |
| CHEMBL3586052 | — | IC50 | = | 63.08 | nM | 7.20 |
| CHEMBL3586070 | — | IC50 | = | 99.58 | nM | 7.00 |
| CHEMBL3586058 | — | IC50 | = | 722.38 | nM | 6.14 |
| CHEMBL3586050 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3586053 | — | IC50 | - | — | - | |
| CHEMBL3586054 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3586055 | — | IC50 | - | — | - | |
| CHEMBL3586059 | — | IC50 | - | — | - | |
| CHEMBL3586060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3586061 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3586063 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3586064 | — | IC50 | - | — | - | |
| CHEMBL3586066 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3586062 | — | IC50 | - | — | - | |
| CHEMBL3586067 | — | IC50 | - | — | - | |
| CHEMBL3586068 | — | IC50 | - | — | - | |
| CHEMBL3586075 | — | IC50 | - | — | - | |
| CHEMBL3586069 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3586074 | — | IC50 | - | — | - | |
| CHEMBL3586073 | — | IC50 | - | — | - |