Assay Detail
Functional
CHEMBL3587280
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Cytotoxicity against human SMMC7721 cells assessed as growth inhibition after 48 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of biphenyl-aryl ureas as novel VEGFR-2 inhibitors. Part 4: exploration of diverse hinge-binding fragments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.05 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586058 | — | — | 1 | 6.77 |
| CHEMBL3586071 | — | — | 1 | 6.72 |
| CHEMBL3586057 | — | — | 1 | 6.66 |
| CHEMBL3586074 | — | — | 1 | 6.52 |
| CHEMBL3586054 | — | — | 1 | 6.51 |
| CHEMBL3586070 | — | — | 1 | 6.51 |
| CHEMBL3586051 | — | — | 1 | 6.44 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.43 |
| CHEMBL3586056 | — | — | 1 | 6.37 |
| CHEMBL3586075 | — | — | 1 | 6.34 |
| CHEMBL3586066 | — | — | 1 | 6.33 |
| CHEMBL3586068 | — | — | 1 | 6.32 |
| CHEMBL3586049 | — | — | 1 | 6.26 |
| CHEMBL3586073 | — | — | 1 | 6.21 |
| CHEMBL3586065 | — | — | 1 | 6.20 |
| CHEMBL3586062 | — | — | 1 | 6.08 |
| CHEMBL3586060 | — | — | 1 | 6.08 |
| CHEMBL3586072 | — | — | 1 | 6.05 |
| CHEMBL3586067 | — | — | 1 | 5.88 |
| CHEMBL3586059 | — | — | 1 | 5.74 |
| CHEMBL3586050 | — | — | 1 | 5.74 |
| CHEMBL3586055 | — | — | 1 | 5.71 |
| CHEMBL3586069 | — | — | 1 | 5.62 |
| CHEMBL3586063 | — | — | 1 | 5.56 |
| CHEMBL3586061 | — | — | 1 | 5.54 |
| CHEMBL3586052 | — | — | 1 | 5.53 |
| CHEMBL3586064 | — | — | 1 | 5.12 |
| CHEMBL3586053 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586058 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3586071 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3586057 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3586074 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3586054 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3586070 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3586051 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3586056 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3586075 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3586066 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3586068 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3586049 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3586073 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3586065 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3586062 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3586060 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3586072 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3586067 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3586059 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL3586050 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL3586055 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3586069 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL3586063 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3586061 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL3586052 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL3586064 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL3586053 | — | IC50 | = | 54290.0 | nM | 4.26 |