Assay Detail
Binding
CHEMBL3587283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of menin-MLL1 interaction (unknown origin) incubated for 1 hr by fluorescein and Texas Red labeled MBM1 based fluorescence polarization assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Menin/Histone-lysine N-methyltransferase MLL (CHEMBL2093861) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.40 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586086 | — | — | 1 | 7.05 |
| CHEMBL3126199 | — | — | 1 | 6.94 |
| CHEMBL3126188 | — | — | 1 | 6.71 |
| CHEMBL3126190 | — | — | 1 | 6.65 |
| CHEMBL3126192 | — | — | 1 | 6.62 |
| CHEMBL3586088 | — | — | 1 | 6.61 |
| CHEMBL3126191 | — | — | 1 | 6.52 |
| CHEMBL3586087 | — | — | 1 | 6.45 |
| CHEMBL3126185 | — | — | 1 | 6.41 |
| CHEMBL3126189 | — | — | 1 | 6.36 |
| CHEMBL3586085 | — | — | 1 | 6.34 |
| CHEMBL3586084 | — | — | 1 | 5.96 |
| CHEMBL3585356 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586086 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3126199 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3126188 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3126190 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL3126192 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL3586088 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL3126191 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL3586087 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL3126185 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3126189 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL3586085 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3586084 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3585356 | — | IC50 | = | 28000.0 | nM | 4.55 |