Assay Detail
Binding
CHEMBL3587377
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Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hr
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.61 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586404 | ONATASERTIB | 2.0 | 1 | 7.52 |
| CHEMBL3586394 | — | — | 1 | 6.70 |
| CHEMBL3586398 | — | — | 1 | 6.64 |
| CHEMBL3585359 | — | — | 1 | 6.62 |
| CHEMBL3586381 | — | — | 1 | 6.62 |
| CHEMBL3586403 | — | — | 1 | 6.47 |
| CHEMBL2348862 | — | — | 1 | 6.41 |
| CHEMBL3586402 | — | — | 1 | 6.28 |
| CHEMBL3586391 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586404 | ONATASERTIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3586394 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3586398 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3585359 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3586381 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3586403 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2348862 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3586402 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3586391 | — | IC50 | = | 650.0 | nM | 6.19 |