Assay Detail
Binding
CHEMBL3587380
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Inhibition of mTORC2 in human PC3 cells assessed as inhibition of Akt phosphorylation at S473 after 1 hr
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586404 | ONATASERTIB | 2.0 | 1 | 8.00 |
| CHEMBL3585359 | — | — | 1 | 7.05 |
| CHEMBL3586381 | — | — | 1 | 6.96 |
| CHEMBL3586394 | — | — | 1 | 6.89 |
| CHEMBL3586398 | — | — | 1 | 6.80 |
| CHEMBL2348862 | — | — | 1 | 6.50 |
| CHEMBL3586402 | — | — | 1 | 6.48 |
| CHEMBL3586403 | — | — | 1 | 6.46 |
| CHEMBL3586391 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586404 | ONATASERTIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3585359 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3586381 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3586394 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3586398 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2348862 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3586402 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3586403 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3586391 | — | IC50 | = | 610.0 | nM | 6.21 |