Assay Detail
Binding
CHEMBL3587522
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Inhibition of mTORC1 in human PC3 cells assessed as inhibition of p70S6K phosphorylation after 1 hr
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.79 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586561 | — | — | 1 | 8.40 |
| CHEMBL3586566 | — | — | 1 | 8.22 |
| CHEMBL3586387 | — | — | 1 | 8.10 |
| CHEMBL3586568 | — | — | 1 | 8.00 |
| CHEMBL3586571 | — | — | 1 | 8.00 |
| CHEMBL3586567 | — | — | 1 | 7.92 |
| CHEMBL3586562 | — | — | 1 | 7.57 |
| CHEMBL3586572 | — | — | 1 | 7.28 |
| CHEMBL3586559 | — | — | 1 | 7.27 |
| CHEMBL3586570 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586561 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3586566 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3586387 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3586568 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3586571 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3586567 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3586562 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3586572 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3586559 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3586570 | — | IC50 | = | 66.0 | nM | 7.18 |