Assay Detail
Functional
CHEMBL3587537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human dopamine D2L receptor expressed in CHO cell membranes after 1 hr by [35S]-GTPgammaS binding assay
24
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of novel ropinirole analogues: synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 7.21 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3585370 | — | — | 2 | 8.41 |
| CHEMBL3585371 | — | — | 2 | 8.21 |
| CHEMBL3585372 | — | — | 2 | 7.85 |
| CHEMBL3585369 | — | — | 2 | 7.66 |
| CHEMBL3585368 | — | — | 2 | 7.55 |
| CHEMBL3585367 | — | — | 2 | 7.38 |
| CHEMBL155731 | QUINELORANE | 2.0 | 2 | 7.35 |
| CHEMBL3585364 | — | — | 2 | 7.26 |
| CHEMBL3585363 | — | — | 2 | 7.07 |
| CHEMBL3585365 | — | — | 2 | 6.66 |
| CHEMBL3585366 | — | — | 2 | 5.85 |
| CHEMBL3585373 | — | — | 2 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3585370 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3585370 | — | EC50 | = | 3.89 | nM | 8.41 |
| CHEMBL3585371 | — | EC50 | = | 6.166 | nM | 8.21 |
| CHEMBL3585371 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3585372 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL3585372 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3585369 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3585369 | — | EC50 | = | 22.39 | nM | 7.65 |
| CHEMBL3585368 | — | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL3585368 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3585367 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL3585367 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL155731 | QUINELORANE | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL155731 | QUINELORANE | EC50 | = | 44.67 | nM | 7.35 |
| CHEMBL3585364 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3585364 | — | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL3585363 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3585363 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL3585365 | — | EC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3585365 | — | EC50 | = | 218.78 | nM | 6.66 |
| CHEMBL3585366 | — | EC50 | = | 1413.0 | nM | 5.85 |
| CHEMBL3585366 | — | EC50 | = | 1445.44 | nM | 5.84 |
| CHEMBL3585373 | — | EC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL3585373 | — | EC50 | = | 4677.0 | nM | 5.33 |