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Assay Detail

CHEMBL3587634

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and evaluation of artesunateindoloquinoline hybrids as antimalarial drug candidates
Wang N, Wicht KJ, Shaban E, Ngoc TA, Wang M, Hayashi I, Hossain MI, Takemasa Y, Kaiser M, El Tantawy El Sayed I, Egan TJ, Inokuchi T
Medchemcomm (2014) 5 : 927 -931
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 8.61 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3585410 1 9.40
CHEMBL3585406 1 9.39
CHEMBL3585404 1 9.38
CHEMBL3585411 1 9.17
CHEMBL3585405 1 9.03
CHEMBL3585407 1 9.02
CHEMBL3585408 1 9.00
CHEMBL3585409 1 8.94
CHEMBL269671 ARTEMISININ 3.0 1 8.55
CHEMBL2391246 1 7.66
CHEMBL3233348 1 7.08
CHEMBL76 CHLOROQUINE 4.0 1 6.68
CHEMBL3585412 1 -
CHEMBL2058009 1 -
CHEMBL3585413 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3585410 IC50 = 0.4 nM 9.40
CHEMBL3585406 IC50 = 0.41 nM 9.39
CHEMBL3585404 IC50 = 0.42 nM 9.38
CHEMBL3585411 IC50 = 0.67 nM 9.17
CHEMBL3585405 IC50 = 0.93 nM 9.03
CHEMBL3585407 IC50 = 0.95 nM 9.02
CHEMBL3585408 IC50 = 1.0 nM 9.00
CHEMBL3585409 IC50 = 1.15 nM 8.94
CHEMBL269671 ARTEMISININ IC50 = 2.8 nM 8.55
CHEMBL2391246 IC50 = 22.1 nM 7.66
CHEMBL3233348 IC50 = 82.7 nM 7.08
CHEMBL76 CHLOROQUINE IC50 = 209.5 nM 6.68
CHEMBL3585412 IC50 - -
CHEMBL2058009 IC50 - -
CHEMBL3585413 IC50 - -