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Assay Detail

CHEMBL3587637

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to heme assessed as inhibition of beta-hematin formation by NP40 detergent based assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Target

Heme (CHEMBL4651321)
Type SMALL MOLECULE

Publication

Synthesis and evaluation of artesunateindoloquinoline hybrids as antimalarial drug candidates
Wang N, Wicht KJ, Shaban E, Ngoc TA, Wang M, Hayashi I, Hossain MI, Takemasa Y, Kaiser M, El Tantawy El Sayed I, Egan TJ, Inokuchi T
Medchemcomm (2014) 5 : 927 -931
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.55 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3585411 1 4.80
CHEMBL3585412 1 4.77
CHEMBL3585413 1 4.77
CHEMBL3585409 1 4.59
CHEMBL3585407 1 4.54
CHEMBL3585408 1 4.53
CHEMBL76 CHLOROQUINE 4.0 1 4.52
CHEMBL3585406 1 4.42
CHEMBL3585410 1 4.38
CHEMBL3585405 1 4.15
CHEMBL3585404 1 -
CHEMBL2058009 1 -
CHEMBL2391246 1 -
CHEMBL3233348 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3585411 IC50 = 15690.0 nM 4.80
CHEMBL3585412 IC50 = 17120.0 nM 4.77
CHEMBL3585413 IC50 = 16820.0 nM 4.77
CHEMBL3585409 IC50 = 25790.0 nM 4.59
CHEMBL3585407 IC50 = 28880.0 nM 4.54
CHEMBL3585408 IC50 = 29240.0 nM 4.53
CHEMBL76 CHLOROQUINE IC50 = 30000.0 nM 4.52
CHEMBL3585406 IC50 = 37780.0 nM 4.42
CHEMBL3585410 IC50 = 41660.0 nM 4.38
CHEMBL3585405 IC50 = 70160.0 nM 4.15
CHEMBL3585404 IC50 = 222500.0 nM -
CHEMBL2058009 IC50 - -
CHEMBL2391246 IC50 = 104400.0 nM -
CHEMBL3233348 IC50 = 626800.0 nM -