Assay Detail
Binding
CHEMBL3587751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rabbit hind leg muscle SERCA1a by pyruvate kinase and lactate dehydrogenase coupled assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Leg |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL4693) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Inhibitors and Structure-Activity Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.44 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2059712 | ALISOL B | — | 1 | 4.57 |
| CHEMBL3586100 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2059712 | ALISOL B | Kd | = | 27000.0 | nM | 4.57 |
| CHEMBL3586100 | — | Kd | = | 50000.0 | nM | 4.30 |