Assay Detail
Binding
CHEMBL3588512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.49 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 6.37 |
| CHEMBL3586211 | — | — | 1 | - |
| CHEMBL3586212 | — | — | 1 | - |
| CHEMBL3586213 | — | — | 1 | - |
| CHEMBL3586214 | — | — | 1 | - |
| CHEMBL3586215 | — | — | 1 | - |
| CHEMBL3586216 | — | — | 1 | - |
| CHEMBL3586217 | — | — | 1 | - |
| CHEMBL3586218 | — | — | 1 | - |
| CHEMBL3310916 | — | — | 1 | - |
| CHEMBL3586219 | — | — | 1 | - |
| CHEMBL3586220 | — | — | 1 | - |
| CHEMBL3586221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL897 | PROBENECID | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL3586211 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586212 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586213 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586214 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586215 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586216 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586217 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586218 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3310916 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586219 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586220 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3586221 | — | Ki | > | 10000.0 | nM | - |