Assay Detail
Binding
CHEMBL3588577
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Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.35 | 10.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3585778 | — | — | 1 | 10.31 |
| CHEMBL3585775 | — | — | 1 | 10.22 |
| CHEMBL3585777 | — | — | 1 | 10.05 |
| CHEMBL3585779 | — | — | 1 | 9.98 |
| CHEMBL3585784 | — | — | 1 | 9.86 |
| CHEMBL3585776 | — | — | 1 | 9.81 |
| CHEMBL3585780 | — | — | 1 | 9.71 |
| CHEMBL3585783 | — | — | 1 | 9.42 |
| CHEMBL3585782 | — | — | 1 | 9.34 |
| CHEMBL3585781 | — | — | 1 | 9.17 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3585778 | — | Ki | = | 0.0488 | nM | 10.31 |
| CHEMBL3585775 | — | Ki | = | 0.0603 | nM | 10.22 |
| CHEMBL3585777 | — | Ki | = | 0.0888 | nM | 10.05 |
| CHEMBL3585779 | — | Ki | = | 0.1051 | nM | 9.98 |
| CHEMBL3585784 | — | Ki | = | 0.1368 | nM | 9.86 |
| CHEMBL3585776 | — | Ki | = | 0.1561 | nM | 9.81 |
| CHEMBL3585780 | — | Ki | = | 0.1927 | nM | 9.71 |
| CHEMBL3585783 | — | Ki | = | 0.3838 | nM | 9.42 |
| CHEMBL3585782 | — | Ki | = | 0.4539 | nM | 9.34 |
| CHEMBL3585781 | — | Ki | = | 0.6722 | nM | 9.17 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 184.3 | nM | 6.73 |