Assay Detail
Binding
CHEMBL3590746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (-)-[3H]vesamicol from VAChT in Torpedo californica electric organ synaptic vesicles
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vesicular acetylcholine transporter (CHEMBL3313) ↗| Type | SINGLE PROTEIN |
| Organism | Torpedo californica |
Publication
New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.11 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87381 | — | — | 1 | 10.89 |
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | 10.26 |
| CHEMBL264437 | — | — | 1 | 9.47 |
| CHEMBL473129 | — | — | 1 | 8.57 |
| CHEMBL1089853 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87381 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL87379 | BENZOVESAMICOL | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL264437 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL473129 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1089853 | — | Ki | = | 423.0 | nM | 6.37 |