Assay Detail
Binding
CHEMBL3590774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 3 subunit alpha (CHEMBL5163) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.06 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589893 | — | — | 1 | 5.46 |
| CHEMBL3589892 | — | — | 1 | 5.16 |
| CHEMBL3589894 | — | — | 1 | 4.85 |
| CHEMBL741 | LAMOTRIGINE | 4.0 | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589893 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3589892 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3589894 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL741 | LAMOTRIGINE | IC50 | = | 17000.0 | nM | 4.77 |