Assay Detail
Binding
CHEMBL3590959
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Binding affinity to delta opioid receptor (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.63 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1455766 | — | — | 1 | 5.96 |
| CHEMBL3590195 | — | — | 1 | 5.63 |
| CHEMBL3590193 | — | — | 1 | 5.29 |
| CHEMBL3590199 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1455766 | — | Ki | = | 1088.0 | nM | 5.96 |
| CHEMBL3590195 | — | Ki | = | 2328.0 | nM | 5.63 |
| CHEMBL3590193 | — | Ki | = | 5190.0 | nM | 5.29 |
| CHEMBL3590199 | — | Ki | > | 10000.0 | nM | - |