Assay Detail
Binding
CHEMBL3591124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.65 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3588920 | — | — | 1 | 7.63 |
| CHEMBL3588913 | — | — | 1 | 7.50 |
| CHEMBL3588982 | — | — | 1 | 7.37 |
| CHEMBL3588981 | — | — | 1 | 7.36 |
| CHEMBL3588919 | — | — | 1 | 7.33 |
| CHEMBL3588921 | — | — | 1 | 7.30 |
| CHEMBL3588915 | — | — | 1 | 7.29 |
| CHEMBL3588987 | — | — | 1 | 7.27 |
| CHEMBL3353895 | — | — | 1 | 7.27 |
| CHEMBL3589652 | — | — | 1 | 7.26 |
| CHEMBL3588986 | — | — | 1 | 7.25 |
| CHEMBL3588914 | — | — | 1 | 7.24 |
| CHEMBL3588983 | — | — | 1 | 7.16 |
| CHEMBL3588917 | — | — | 1 | 7.09 |
| CHEMBL3588916 | — | — | 1 | 7.08 |
| CHEMBL3588984 | — | — | 1 | 6.99 |
| CHEMBL2430443 | — | — | 1 | 6.86 |
| CHEMBL3588989 | — | — | 1 | 6.72 |
| CHEMBL3589650 | — | — | 1 | 6.61 |
| CHEMBL3589651 | — | — | 1 | 6.49 |
| CHEMBL3588918 | — | — | 1 | 6.37 |
| CHEMBL3588994 | — | — | 1 | 6.37 |
| CHEMBL3588993 | — | — | 1 | 6.22 |
| CHEMBL1627305 | — | — | 1 | 6.13 |
| CHEMBL3588997 | — | — | 1 | 6.10 |
| CHEMBL3588990 | — | — | 1 | 6.09 |
| CHEMBL3588985 | — | — | 1 | 6.05 |
| CHEMBL3588998 | — | — | 1 | 6.02 |
| CHEMBL3588992 | — | — | 1 | 5.99 |
| CHEMBL3588991 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3588920 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL3588913 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL3588982 | — | Ki | = | 42.5 | nM | 7.37 |
| CHEMBL3588981 | — | Ki | = | 43.7 | nM | 7.36 |
| CHEMBL3588919 | — | Ki | = | 46.6 | nM | 7.33 |
| CHEMBL3588921 | — | Ki | = | 50.1 | nM | 7.30 |
| CHEMBL3588915 | — | Ki | = | 51.8 | nM | 7.29 |
| CHEMBL3588987 | — | Ki | = | 53.9 | nM | 7.27 |
| CHEMBL3353895 | — | Ki | = | 53.6 | nM | 7.27 |
| CHEMBL3589652 | — | Ki | = | 54.7 | nM | 7.26 |
| CHEMBL3588986 | — | Ki | = | 56.1 | nM | 7.25 |
| CHEMBL3588914 | — | Ki | = | 57.2 | nM | 7.24 |
| CHEMBL3588983 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL3588917 | — | Ki | = | 80.8 | nM | 7.09 |
| CHEMBL3588916 | — | Ki | = | 83.4 | nM | 7.08 |
| CHEMBL3588984 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL2430443 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL3588989 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL3589650 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL3589651 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL3588918 | — | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL3588994 | — | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL3588993 | — | Ki | = | 607.0 | nM | 6.22 |
| CHEMBL1627305 | — | Ki | = | 746.0 | nM | 6.13 |
| CHEMBL3588997 | — | Ki | = | 789.0 | nM | 6.10 |
| CHEMBL3588990 | — | Ki | = | 819.0 | nM | 6.09 |
| CHEMBL3588985 | — | Ki | = | 885.0 | nM | 6.05 |
| CHEMBL3588998 | — | Ki | = | 963.0 | nM | 6.02 |
| CHEMBL3588992 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL3588991 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL3588988 | — | Ki | = | 2590.0 | nM | 5.59 |
| CHEMBL3588996 | — | Ki | = | 15100.0 | nM | 4.82 |
| CHEMBL3588995 | — | Ki | = | 18800.0 | nM | 4.73 |