Assay Detail
Binding
CHEMBL3591366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.25 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.46 |
| CHEMBL3590086 | — | — | 1 | 7.33 |
| CHEMBL300780 | — | — | 1 | 7.26 |
| CHEMBL180010 | — | — | 1 | 7.13 |
| CHEMBL1627314 | — | — | 1 | 6.66 |
| CHEMBL3590085 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.343 | nM | 9.46 |
| CHEMBL3590086 | — | Ki | = | 46.9 | nM | 7.33 |
| CHEMBL300780 | — | Ki | = | 54.7 | nM | 7.26 |
| CHEMBL180010 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL1627314 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL3590085 | — | Ki | = | 2110.0 | nM | 5.68 |