Assay Detail
Binding
CHEMBL3591367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.03 | 9.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300780 | — | — | 1 | 9.63 |
| CHEMBL180010 | — | — | 1 | 9.50 |
| CHEMBL1627314 | — | — | 1 | 9.04 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.00 |
| CHEMBL3590086 | — | — | 1 | 8.52 |
| CHEMBL3590085 | — | — | 1 | 8.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300780 | — | Ki | = | 0.233 | nM | 9.63 |
| CHEMBL180010 | — | Ki | = | 0.316 | nM | 9.50 |
| CHEMBL1627314 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3590086 | — | Ki | = | 3.04 | nM | 8.52 |
| CHEMBL3590085 | — | Ki | = | 3.15 | nM | 8.50 |