Assay Detail
Binding
CHEMBL3591368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.78 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.24 |
| CHEMBL180010 | — | — | 1 | 6.26 |
| CHEMBL1627314 | — | — | 1 | 5.69 |
| CHEMBL3590086 | — | — | 1 | 5.62 |
| CHEMBL300780 | — | — | 1 | 5.43 |
| CHEMBL3590085 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 57.1 | nM | 7.24 |
| CHEMBL180010 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL1627314 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL3590086 | — | Ki | = | 2370.0 | nM | 5.62 |
| CHEMBL300780 | — | Ki | = | 3670.0 | nM | 5.43 |
| CHEMBL3590085 | — | Ki | = | 35600.0 | nM | 4.45 |