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Assay Detail

CHEMBL3591418

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against African green monkey Vero cells assessed as cell viability by MTT assay
38
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Chlorocebus sabaeus
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Vero (CHEMBL391)
Type CELL-LINE
Organism Chlorocebus sabaeus

Publication

Synthesis and cancer cell growth inhibitory activity of icaritin derivatives.
Wang C, Wu P, Shi JF, Jiang ZH, Wei XY.
Eur J Med Chem (2015) 100 : 139 -150
PubMed 26079090 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 5.11 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3589816 1 5.85
CHEMBL3589817 1 5.85
CHEMBL3590170 1 5.51
CHEMBL3589408 1 5.36
CHEMBL83 TAMOXIFEN 4.0 1 5.24
CHEMBL3589409 1 5.24
CHEMBL3589418 1 5.20
CHEMBL3589407 1 5.19
CHEMBL3589410 1 5.15
CHEMBL3589417 1 4.84
CHEMBL3589412 1 4.71
CHEMBL498485 ICARITIN 3.0 1 4.67
CHEMBL3589827 1 4.44
CHEMBL3589829 1 4.25
CHEMBL3589819 1 -
CHEMBL498486 1 -
CHEMBL3589820 1 -
CHEMBL3589401 1 -
CHEMBL3589822 2 -
CHEMBL3589823 1 -
CHEMBL3589824 1 -
CHEMBL3589825 1 -
CHEMBL3589826 1 -
CHEMBL3589828 1 -
CHEMBL3589821 1 -
CHEMBL3589411 1 -
CHEMBL3589413 1 -
CHEMBL3589416 1 -
CHEMBL3589415 1 -
CHEMBL3589414 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3589816 IC50 = 1400.0 nM 5.85
CHEMBL3589817 IC50 = 1400.0 nM 5.85
CHEMBL3590170 IC50 = 3100.0 nM 5.51
CHEMBL3589408 IC50 = 4400.0 nM 5.36
CHEMBL83 TAMOXIFEN IC50 = 5700.0 nM 5.24
CHEMBL3589409 IC50 = 5800.0 nM 5.24
CHEMBL3589418 IC50 = 6300.0 nM 5.20
CHEMBL3589407 IC50 = 6500.0 nM 5.19
CHEMBL3589410 IC50 = 7100.0 nM 5.15
CHEMBL3589417 IC50 = 14500.0 nM 4.84
CHEMBL3589412 IC50 = 19300.0 nM 4.71
CHEMBL498485 ICARITIN IC50 = 21600.0 nM 4.67
CHEMBL3589827 IC50 = 36600.0 nM 4.44
CHEMBL3589829 IC50 = 55900.0 nM 4.25
CHEMBL3589402 IC50 - -
CHEMBL3589402 IC50 - -
CHEMBL3589403 IC50 - -
CHEMBL3589404 IC50 - -
CHEMBL3589405 IC50 - -
CHEMBL3589406 IC50 - -
CHEMBL3589818 IC50 - -
CHEMBL3589819 IC50 - -
CHEMBL498486 IC50 - -
CHEMBL3589820 IC50 - -
CHEMBL3589401 IC50 - -
CHEMBL3589822 IC50 - -
CHEMBL3589822 IC50 - -
CHEMBL3589823 IC50 - -
CHEMBL3589824 IC50 - -
CHEMBL3589825 IC50 - -
CHEMBL3589826 IC50 - -
CHEMBL3589828 IC50 - -
CHEMBL3589821 IC50 - -
CHEMBL3589411 IC50 - -
CHEMBL3589416 IC50 > 100000.0 nM -
CHEMBL3589415 IC50 - -
CHEMBL3589414 IC50 - -
CHEMBL3589413 IC50 - -