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Assay Detail

CHEMBL3591434

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Binding
Inhibition of NBD-cholesterol binding to recombinant Aedes aegypti SCP-2 protein by fluorescence based assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Aedes aegypti
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sterol carrier protein 2 (CHEMBL3588733)
Type SINGLE PROTEIN
Organism Aedes aegypti

Publication

Thiosemicarbazones as Aedes aegypti larvicidal.
da Silva JB, Navarro DM, da Silva AG, Santos GK, Dutra KA, Moreira DR, Ramos MN, Espíndola JW, de Oliveira AD, Brondani DJ, Leite AC, Hernandes MZ, Pereira VR, da Rocha LF, de Castro MC, de Oliveira BC, Lan Q, Merz KM.
Eur J Med Chem (2015) 100 : 162 -175
PubMed 26087027 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 5.76 6.22
Inhibition 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3589422 2 6.22
CHEMBL242113 2 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3589422 EC50 = 600.0 nM 6.22
CHEMBL242113 EC50 = 5000.0 nM 5.30
CHEMBL242113 Inhibition - % -
CHEMBL3589422 Inhibition - % -